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In addition, the gastrointestinal tract is an organ that directly communicates with the outside environment, and intestinal microbes play an essential role in maintaining the normal function of the intestinal tract

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Besides,the oxidative stress increases and the metabolism or MMP decreases significantly

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doi: 10.1016/j.ijfoodmicro.2014.07.017 Summary Keywords Oenococcus oeni , metabolism, malolactic fermentation, random mutagenesis, ethanol resistance Citation Contreras , Daz G, Mendoza SN, Canto M and Agosn E (2023) Metabolic behavior for a mutant Oenococcus oeni strain with high resistance to ethanol to survive under oenological multi-stress conditions

These pathological changes significantly impair the efficiency of ventilationperfusion matching, leading to a vicious cycle of restrictive ventilatory dysfunction and impaired diffusion capacity