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Mitochondrial damage was reversed, GPX4 levels increased, and lipid peroxidation was reversed

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In the methionine cycle, methionine receives adenosine from ATP, which then creates SAM-e (s-adenosyl-methionine)

Apocynin is a bioactive phenol extracted from the roots of Apocynum venetum L., and as a NOX2 inhibitor, it can prevent ROS production and reduce inflammatory responses (Philippens et al., 2013)