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doi:10.4103/1673-5374.320969 Knezevic M, Gojkovic S, Krezic I, et al

Renal toxicity may be greater in patients with underlying renal impairment or with other risk factors, including advanced age or dehydration

However, the long-term health consequences of low or high fluid intake have been poorly investigated

If you have been considering peptide pills or other supplements for weight loss, it is worth discussing this openly during your appointment your doctor can help you assess whether a product is safe, regulated, and likely to be effective

Specifically, the global deletion of Zip14 in mice led to an increased ratio of fungi to bacteria in the fecal microbiome, at least partially driven by an increase in Saccharomyces cerevisiae, which has been linked to IBD (141, 142)