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Patients with the temporal lobe epilepsy-depression (TLE-D) phenotype are more prone to cognitive impairment, a finding that further supports the notion that TLE may affect both cognitive and emotional functions through multiple pathophysiological mechanisms (Bingaman et al., 2023)

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Negative findings are plausibly attributable to suboptimal dosing or treatment duration, lack of stratification by baseline deficiency status or metabolic phenotype, and confounding from sedation practices and illness severity 85

doi: 10.1016/j.ijbiomac.2020.02.044 49 LiLWeiNMinZQLiYZhangXWuHyet al

First, the specific pathogenic or protective microbial species, microbial-derived metabolites, and mimic antigens relevant to different NIU subtypes remain to be identified

Skendros P, Papagoras C, Lefaki I, et al