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A constantly expanding body of evidence indicates that TDM may be a valuable clinical tool for improving disease outcomes and can be applied in either reactive or pre-active fashion [136]

These physical crystals can cause mechanical damage (shearing) to the delicate secondary and tertiary structures of the peptide chains

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In the case of ischemic stroke, reactive astrocytes also contribute to BBB permeability through the Wnt/-catenin pathway as demonstrated in an Nhe1 conditional knockout mouse model 119