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It has been found that treatment with proteasome inhibitors such as MG132 or lactacystin induces secondary axotomy of stretch-injured axons 72 h after the injury (Du et al., 2008), and arrests neurite outgrowth in primary cultured neurons (Laser et al., 2003)

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doi: 10.1016/s0197-4580(97)00111-5 230

2-Oxatricyclo [4.3.1.0(3,8)] decane exhibited a free energy of binding of 4.15 kcal/mol, suggesting a moderate binding affinity with the MexAB-OprM efflux pump.The inhibition constant (Ki) was determined to be 906.56 m, indicating a moderate inhibitory activity against the MexAB-OprM efflux pump