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Microglial synaptic pruning and stress-induced dysregulation TREM 2 phosphatidylserine signaling and stress-induced impairment Microglia eliminate dysfunctional synapses by recognizing phosphatidylserine (PS), a lipid exposed on compromised neuronal membranes, through the triggering receptor expressed on myeloid cells 2 (TREM2) (158, 162, 179)

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