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Comparision of human and parasite Trx-2 suggests that the first helix and sheet in PfTrx-2 are displaced relative to HuTrx-2

These observations may help explain why RA is a site-specific manifestation of a systemic autoimmune disease, in which early cartilage damage in the context of altered immune activation leads to a specific cellular activation of FLS within the articular joints

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Results Heterogeneity of metabolic pathway in cancer cells The metabolic pathways from the Human-GEM model were scored based on scRNA-seq data to characterize malignant heterogeneity in gynecologic and breast cancers

The protein was purified by gel filtration using a 120 ml Superdex 75 column (GE Healthcare, Munich, Germany)