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Similarly, in oncology, zinc-based nanomaterials have been used to induce ER stress and the UPR, culminating in immunogenic cell death and enhancing the efficacy of immune checkpoint blockade therapies 181,182

Clinically, knowledgeable providers may explore off-label pharmaceutical treatments such as Low Dose Naltrexone (LDN), which has shown significant promise in modulating microglial activation

A real-world cohort study looked at the risks of developing ICIP in NSCLC patients who received prior radiotherapy and are currently on ICI therapy

1ce, the severe group had significantly more acyl-CoA synthetase long chain family member 4 (ACSL4)-positive cells than the mild group but fewer glutathione peroxidase 4 (GPX4)- and ferritin heavy chain 1(FTH1)-positive cells

doi: 10.1016/j.dld.2018.09.017 179 ZhuX.TangW.FanZ.SunS.TanX

Agrawal, G