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CpGs do not have an even distribution throughout the genome, as they tend to assemble in their unmethylated form in areas called CpG islands (CGIs), which are usually associated with gene promoters [13]

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In line with our expectations, the cotreatment of CuSO 4 with a GHK tripeptide at every concentration tested minimized the effect of CuSO 4 , which was shown by a similar value in both sd1 and sd2 (Figure 5A)