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It is worth mentioning another GLP-1RA, dulaglutide, which is an FDA-approved drug for the treatment of T2DM and contributes to the reduction in cardiovascular mortality in diabetic patients

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As shown in Figure 3C, the keto group of ring A interacts with the side chains of amino acids Q711 and R752, whereas the hydroxyl group at the 17-position hydrogen-bonds with the side chains of N705 and T877