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Interestingly, the PARP inhibitor olaparib has shown a significant improvement in OS when added to paclitaxel as second-line therapy in a phase II study enrolling Asian patients with advanced GEA, particularly in the molecular subset with ataxia-telangiectasia mutated protein (ATM)-negative tumors (77)

Together, these observations suggest that even if NAM can act as an inhibitor of NAD + -consuming enzymes in vitro, the outcomes of in vivo NAM administration are more complex

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Kaempferol reverses the abnormal elevation of TCA cycle-related metabolites such as succinic acid and citric acid in the plasma of PAH rats by regulating amino acid metabolism and arachidonic acid metabolism, downregulates the pro-inflammatory metabolite 12-HETE, upregulates the anti-inflammatory metabolite DHA, and inhibits the expression of PTGS1 (Yi et al., 2022)