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Studies such as VARSITY show that it has a higher endoscopic remission rate in UC compared to adalimumab, and similar efficacy in CD, making it suitable for patients with anti-TNF failure or intolerance [323]

In light of these findings, SHMT has garnered significant attention as a promising therapeutic target

Food and Drug Administration, and these products are not intended to diagnose, treat, cure, or prevent any disease

Total absence of functional acid labile subunit, resulting in severe insulin-like growth factor deficiency and moderate growth failure