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Description

J Vasc Surg

We explore the risks of using a questionable mewing device and why a self-guided mewing jawline exercise often leads to frustration and potential discomfort

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Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)

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Funding: The research described in this manuscript was supported by grant 108-1083570-3635, Ministry of Science, Education and Sports, Republic of Croatia