l cysteine glutathione disulfide Disulfides (Cys-ss-X) as Sensitive Plasma Biomarkers of Oxidative Stress L-Cysteine-glutathione disulfide | Biomarkers for

10.1016/j.cmet.2024.07.009 75 LillR.FreibertS

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Overall, these newly uncovered metabolic reactions fill gaps in the metabolic network maps, facilitating exploration of uncharted territories in cellular biochemistry

V 1985 Sies Redox framework Dsseldorf Helmut Sies, working at the University of Dsseldorf, formulates the broader conceptual framework of cellular oxidant-and-antioxidant balance integrating decades of accumulated observation on glutathione biology into a coherent cellular framework that the field continues to work within

While a mixed-model approach may be considered for retaining related individuals while controlling for relatedness, the analytic framework of our study required the removal of closely related samples to ensure independence of observations