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About 90% of cases are sporadic and of unknown origin, while ~ 10% are familial (FALS)

Nature 329 , 219222 (1987)

Jenn Simmons: Well, I think it starts from screening

In addition, the tubular ultrafiltrate from nephrotic rats stimulated collagen types I and IV synthesis in cultured tubular cells, suggesting that the excessive losses of IGF-1 in the nephrotic state may promote tubular-interstitial fibrosis and thereby, progressive kidney disease in patients with persistent nephrotic syndrome [219]