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118 (39) e2110610118

Neurochemical Journal , 14, 314-320

Although various drugs and compounds have been listed that can target the MET channel to alleviate ototoxicity caused by cisplatin or aminoglycosides, most of these compounds, such as d-Tubocurarine, Phenoxybenzamine, and Carvedilol, not only fail to provide ear protection at high concentrations but also enhance ototoxicity, with a narrow effective dose window limiting the practical clinical application of many MET channel blockers

The biochemical one is that B vitamins, B12 in particular, are cofactors in the same one-carbon and methylation chemistry that the lipotropics feed into, so they complement the methionine cycle described above

Solution: The added HCl (a strong acid) or NaOH (a strong base) will react completely with formate (a weak base) or formic acid (a weak acid), respectively, to give formic acid or formate and water

American Diabetes Association 85th Scientific Sessions, ADA Meeting News, June 22, 2025 (Garvey presentation)