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Results: Cirrhosis was significantly associated with male sex (11/12 cirrhotic patients, Fischers exact p =0.036), increased aspartate aminotransferase (AST) (median 64 vs 44.5 U/L, p =0.034), decreased platelets (102 vs 174 K/mcL, p =0.0009), increased liver stiffness (n=27, 15.0 vs 9.95 kPa, p =0.022), and increased hepatic venous pressure gradients (n=34, 8.0 vs 4.5 mmHg, p =0.0057)

These compounds exert neuroprotective effects by modulating key signaling pathways, such as NF-B and Nrf2, which are central to controlling inflammation and oxidative stress

Inflamm Bowel Dis 24(8):18401848 Telesco SE, Brodmerkel C, Zhang H, Kim LL, Johanns J, Mazumder A et al (2018) Gene expression signature for prediction of golimumab response in a phase 2a open-label trial of patients with ulcerative colitis

In target optimization, high-throughput screening can be applied to establish a screening model for inhibitors based on the core pathway of pulmonary fibrosis (TGF-)

Mechanisms, pathophysiological roles and methods for analyzing mitophagy - recent insights