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Br J Clin Pharmacol 77:947957 Van Roon E, Van De Laar M (2010) Methotrexate bioavailability

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Other reactive species with either oxidizing or nitrating properties include the nitric oxide radical (NO), peroxynitrite (ONOO-), and the lipid peroxyl radical (LOO)

Most excluded studies focused on specific dermatological conditions (acne, psoriasis, radiotherapy-induced dermatitis) rather than addressing general skin health and age-related changes