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Ral Colorado-Peralta, orcid.org/0000-0001-9458-1800 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The control of lipid peroxidation and iron metabolism is one important mechanism

This checkpoint modulation creates permissive conditions for T cell-mediated tumor elimination and provides strong rationale for combining SFN with immune checkpoint inhibitors to overcome therapeutic resistance

An upregulator 4010B-30 has been reported to regulate Apo AI gene expression partly through the peroxisome proliferators-activated receptor -mediated pathway, contributing to increase cholesterol efflux in macrophage cells and reduce atherosclerosis 127