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Research in aging mouse models shows that MOTS-c administration suppresses SASP markers and reduces the burden of senescent cells in metabolically active tissues [2]

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6 Neurosci Biobehav Rev (1984)Graf MV, Kastin AJ Delta-sleep-inducing peptide (DSIP): a review

Palmer TD, Willhoite AR, Gage FH (2000) Vascular niche for adult hippocampal neurogenesis

More recent studies also provided evidence that SDF-1/CXCR4 promoted mobilization and homing of exogenously transplanted NSCs to sites of injury in mouse brains [211, 212]

The following antibodies were used: antibodies against human eNOS, phosphor-eNOS (Ser1177), Cav-1, phosphor-Cav-1 (Tyr14), Src and phosphor-Src (Tyr416) were obtained from Cell Signaling (MA, USA)