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Targeting metabolic processes therefore represents a potential novel strategy to reverse cisplatin resistance

Subsequently, reduced iron Fe 2+ enters enterocytes through divalent metal transporter-1 (DMT1) in the apical membrane (51), is transported into the blood circulation through Ferroportin1 (FPN1) on the intestinal epithelial cell membrane, and is then converted to Fe 3+ by heparin (Hp) or ceruloplasmin (52)

While many chemotherapeutic agents can cause peripheral neuropathy, this is not a universal feature of all such compounds, suggesting that at least some additional mechanisms likely contribute

2) Cell type- and phenotype-specific regulatory blank spots: Most studies have focused on global renal changes or generic cystic cells, but the cell type-specific contribution to ADPKD-related ferroptosis is severely understudied

These results are in accordance with those of previous studies that emphasize the role of H.pylori eradication [62] and exogenous antioxidants in the prevention of gastroduodenal injury, promotion of healing and prevention of relapse [63-65]

The concentration of vitamins was determined using a calibration curve range 1.2520 g/mL ( r 2 = 0.9999) for vitamin C, and 525 mg/L ( r 2 = 0.9999) for vitamin E and normalized for milligrams of protein