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Mitochondrial dysfunction in POI is characterized by a reduction in mitochondrial DNA (mtDNA) copy number, increased oxidative damage, and pathogenic mutations that compromise the oxidative phosphorylation (OXPHOS) system [105]

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This natural chemical upregulates SIRT1 and Nrf2, promoting neuronal longevity and neuroprotective by its anti-inflammatory, anti-oxidative and anti-apoptotic effects in ischemic stroke (126, 127)

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doi: 10.1002/adma.201802244 140 SongXXuJLiangCChaoYJinQWangCet al

With respect to the rejection index, it must be noted that the summation of sighs and apneas under non-eupneic breathing under the rejection index is obviously simplistic and does not do justice to the different mechanisms that elicit these individual respiratory patterns