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smegmatis , including the PEP carboxykinase PckG, the malate synthase GlcB and the citrate synthase AcnA and LpdA2, important for anaplerosis, gluconeogenesis and the TCA cycle

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In susceptible individuals, the hydroxylamine metabolite is unable to be detoxified leading to a cascade of cytotoxic and immunological events that eventually results in the adverse reaction

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Glutathione injections are generally well tolerated