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In the experience of the authors of the present publication, local botulinum toxin application might be considered in single individuals with pain refractory to maximized oral or transdermal treatment, especially in case of on- and off dystonia, muscular pain trigger points, painful myotonus, spasms in the esophagus, pylorus, anal sphincter or hyperactive bladder [29]

Prevention of fistulas and stenosis Patients with IBD are often accompanied by intestinal fistula or intestinal cavity stenosis

doi: 10.3389/fimmu.2023.1139589 Received 07 January 2023 Accepted 20 March 2023 Published 18 April 2023 Volume 14 - 2023 Edited by Qun Zhao, Fourth Hospital of Hebei Medical University, China Reviewed by Laiping Zhong, Shanghai Jiao Tong University, China

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Firstly, the neuroprotective effect of l-lactate is not, or at least not only, dependent on the partial silencing of electrophysiological activity but depends on its use as a metabolic substrate