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[29], Hastings et al

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Glucagon usually gets a bad reputation because it raises blood sugar in isolation

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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

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Section 503A Traditional Compounding FDA describes Category 2 substances (for 503A) as those with identified safety risks pending evaluation, and the agency does not intend to apply the same enforcement discretion it uses for Category 1

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