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Small-molecule inhibitors of the protein methyltransferase SET7/9 identified in a high-throughput screen

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In the context of COVID-19, oxidative stress and inflammation are prominent features of the disease, making antioxidants like glutathione potentially beneficial

[DOI] [PubMed] [Google Scholar] 113.Gurney J.G., Bass J.K., Onar-Thomas A., Huang J., Chintagumpala M., Bouffet E., Hassall T., Gururangan S., Heath J.A., Kellie S., Cohn R., Fisher M.J., Panandiker A.P., Merchant T.E., Srinivasan A., Wetmore C., Qaddoumi I., Stewart C.F., Armstrong G.T., Broniscer A., Gajjar A

Higher levels of these inflammatory cytokines have been found in CSF and serum of patients with ALS and correlate negatively with survival, specifically TNF-alpha, interleukin-10 and interleukin-1 beta [236]