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The sample from the Netherlands Study of Depression and Anxiety included participants with current (n = 1035) or remitted (n = 739) MDD and healthy controls (n = 800)

The atypical energy-related symptom (AES) profile is based on the five items of hypersomnia, increased appetite, increased weight, low energy and leaden paralysis (range 015)

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The asymmetric unit contains an overall of three individual MSA-DH homotetramers which is consistent with our gel filtration and mass photometry experiments

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As a result of the blocking of central A1 adenosine receptors and increased dopaminergic transmission through D2 receptors, ED ingredients increase frontal lobe activity, which reduces fatigue, drowsiness, and improves thought processes