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Description

In fact, 4-methylumbelliferone (the aglycone of 12 ) is an approved drug for biliary spasm in some countries, and its most common side effects are diarrhea and other mild gastrointestinal symptoms 30

In contrast, when sTNF- is tethered to the transmembrane portion of TNF-, the residues of the RSSSRTPS-motif are wound into a helix, blocking the conformational change necessary to envelop the VNAR-D1 binding site