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Nat Cell Biol 11(7):909913

Fourth Human Niagen Study That Demonstrates Effectiveness: A study published in the American Journal of Clinical Nutrition in 2018 concluded that 2,000mg of daily Niagen supplementation over a period of 12 weeks is safe

For example, chelating agents may induce toxicity by binding with other metal ions while off-target effects make copper regulation using copper ion carriers difficult, thus additional studies on how to regulate copper levels are required (180)

We did not investigate the moderating effect of other metabolites as multiple statistical tests would have increased our type I error rate

doi: 10.1016/j.fertnstert.2004.11.022 112 MeseguerMMartinez-ConejeroJOConnorJEPellicerARemohJGarridoN

M.DyerS.Zegers-HochschildF.de MouzonJ.IshiharaO.BankerM.et al (2021)