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Supplementary information This file contains Supplementary discussions 1-5, all of which contain additional rationale and discussion of experimental data and were not included in the main manuscript due to space restrictions

101 Despite major advances in the acknowledgment of tissue-specific NAD + homeostasis, further work will be needed to fully characterize the subcellular and systemic modulation of NAD + metabolism, which can improve the preventive and therapeutic strategies based on maintaining healthy NAD + homeostasis

These days, a rapid reduction in urine production or an abrupt rise in serum creatinine levels over a certain time period might diagnosis acute renal failure (Yoon et al

Our standard packaging includes 2 mL ampoules

Genes of clusters 6 and 7 displayed a decrease expression over time

Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reactive oxygen species, which harm nucleic acids, lipids, and proteins