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Since these fibrinaloid microclots are usually more resistant to fibrinolysis, they are hypothesised to linger in the circulation and have extended contact with the endothelium (313)

44 Moreover, hyperglycemia-induced oxidative stress, AGEs, and chronic inflammation drive glomerular cell senescence through glycogen synthase kinase 3 (GSK3)-modulated nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, impairing repair and worsening inflammation and fibrosis

[45] Weight gain is also possible

SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-kappaB pathway