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A total therapy period of 3 years is recommended to prevent relapses in Japanese consensus guideline [26]

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Specifically, total hepatic CE content in KO mice was 40% lower than in WT mice fed regular chow diet

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Trimer formation was subsequently evaluated using a Renilla luciferase (RLuc)-tagged SLC1A5_var, which facilitates bioluminescence resonance energy transfer (BRET) to the reconstituted YFP fluorescence

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Thus, HDAC inhibitors could theoretically mitigate tinnitus by targeting these convergent pathological hallmarks: aberrant plasticity and inflammation

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