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In vivo experiments in MPS II mice administered g7-NPs-IDS weekly revealed a significant reduction in gel deposition in the brain (Figure 13C) and liver (Figure 13D) tissues, as well as a reduction in LAMP2 (Figure 13E), CD68 (Figure 13F), and GFAP (Figure 13G) markers

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This metabolic shift, a defining hallmark of cancer, involves significant alterations across multiple metabolic pathways

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Collectively, these findings clearly indicated that FGF18 promotes hepatic fibrogenesis, anticipating a novel therapeutic target for prevention and treatment of liver fibrosis