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However, decreased responsiveness to VIM DBS by select body parts (possibly due to the somatotopic organization of the VIM nucleus) increased tolerance to VIM stimulation due to compensation or disease progression [176, 177], and the development of adverse side effects, such as dysarthia and dysphagia [174], in patients, has driven efforts to optimize DBS targeting

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[47] The ( FDA 510(k) summary for the VersaVue TM Single-Use Flexible Cystoscope stated that both devices have the same intended use and similar specifications, and that there are no significant differences

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While the animal studies are intriguing, they are not a substitute for robust human data