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Furthermore, the pan-caspase inhibitor Q-VD prevented APR-246-induced apoptosis without inhibiting ROS elevation (Supplementary Fig

10.1016/j.redox.2021.101975 82 PandianS

First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death