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Journal of Neurochemistry 168(9):27102721 Yan EB et al (2015) Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

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Symptoms may include: strange sensations, numbness, or tingling in the hands, legs, or feet difficulty walking (staggering, balance problems) anemia a swollen, inflamed tongue yellowed skin (jaundice) difficulty thinking and reasoning (cognitive difficulties), or memory loss paranoia or hallucinations weakness fatigue While an experienced physician may be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition

*Correspondence: Liyun Wang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

(2017), shows that certain therapy-resistant cancer cells or those with loss of certain tumour suppressors (such as BRCA1 ) are vulnerable to ferroptosis