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10.1016/j.ncl.2021.04.002 150

Highly efficient and expedited hepatic differentiation from human pluripotent stem cells by pure small-molecule cocktails

K.SrivastavaR.NathS.MohantyT

(eds) editor1983

Unlike nuclear DNA, mtDNA lacks protective histones and has limited DNA repair capacity, rendering it particularly vulnerable to genotoxic stress, such as from reactive oxygen species (ROS) generated during oxidative phosphorylation (OXPHOS) ( The mtDNA encodes 37 genes essential for mitochondrial function: 13 core subunits of the OXPHOS complexes, along with 22 transfer RNAs (tRNAs) and 2 ribosomal RNAs (rRNAs) required for their intramitochondrial translation ( The primary function of mitochondria is the production of ATP through OXPHOS

We also determined whether downregulation of SLC25A33 could modulate M1 polarization of macrophages and limit dysregulated inflammatory responses and the severity of sepsis