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Furthermore, it preserves the structural integrity of astrocytes, especially when these cells experience hypertrophy and hyperplasia in response to CNS damage, which is associated with neuroinflammation and neurodegenerative diseases

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Nephrology 23, 867875

The amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1,000 mg/kg, an preferably in the range of from about 1 to about 100 mg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention

10.1109/EMBC.2015.7318340 117