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doi: 10.3390/biomedicines11061770 53 XuRWuBLiangJHeFGuWLiKet al

Crosslinking density and polymer chemical structures can modulate the stiffness of the final nanocarrier affecting the BBB crossing efficiency and intracellular accumulation of the cargo: as an example, Zheng et al., 2021) demonstrated that lower elasticity of PEG-block-poly(pentafluorophenyl methacrylate) NPs led to increased transcytosis and brain accumulation, despite shorter blood circulation times

Second step is to ensure the observation by carrying out the laboratory tests

Macrocyclic peptides as allosteric inhibitors of nicotinamide N -methyltransferase (NNMT)

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