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While a previous report showed that hemozoin is rapidly ingested by human monocytes and exclusively localized in normally acidified phagolysosomes (Schwarzer et al, 2001), our findings suggest that hemozoin can perturb lysosomal membranes

Ascorbic acid is often referred to as an antioxidant owing to the fact that it prevents other molecules from being consumed by donating electrons [15]

These chemically designed nanomaterials with enzyme-like activity, termed nanozymes, have attracted extensive research interest for biomedical applications such as drug delivery, biosensing, and antimicrobial and antitumor therapies [8, 9]

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10.1093/infdis/155.1.93 83 MukherjeaD.JajooS.SheehanK.KaurT.ShethS.BunchJ.et al (2011)

Lesions of dopamine nigral neurons not only result in depression-like behavior (in the substantia nigra pars compacta) but also lead to a cascade of functional modifications on the activity of basal ganglia circuits, with the dysregulation of the glutamate system.12,13 This pathophysiological mechanism is also shared with Parkinson's disease, with the destabilization of the brain reward mechanism being linked to an increased risk of DE relapse.14 Note, the higher frequency of cardiovascular disorders than in other patients is also associated with the decrease in the activity of GDH, the glutamate-metabolizing enzyme