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In the intention-to-treat analysis, the risk of stroke/SEE was numerically lower with rivaroxaban 15 mg OD versus warfarin (HR [95% CI]: 0.86 [0.631.17], P interaction = 0.85) in patients with CrCl 3049 ml/min, and the risk of major and clinically relevant non-major (CRNM) bleeding was similar between the groups (0.98 [0.841.14], P interaction = 0.45) [59]

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