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(2019) 5:E106875

(Increase in growth hormone receptor expression in tendon fibroblasts)

It is widely studied in regenerative biology, tissue repair, angiogenesis, and gastrointestinal research models

In addition, Sirt1 induces mitophagy through the deacetylation and activation of the mitophagy proteins, including PINK1, PARKIN, and LC3 [37, 39]

However, as the development and testing of remyelination-based therapies requires effective model systems with sustained demyelination and lack of complete endogenous remyelination, we conclude that 1 mM CPZ treatment of brain slice cultures is not a viable ex vivo model for these studies, however, could prove to be useful in acute demyelination studies, pending further characterization