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Typical bicycloheteroaryl groups include, but are not limited to, groups derived from benzofuran, benzimidazole, benzindazole, benzdioxane, chromene, chromane, cinnoline, phthalazine, indole, indoline, indolizine, isobenzofuran, isochromene, isoindole, isoindoline, isoquinoline, benzothiazole, benzoxazole, naphthyridine, benzoxadiazole, pteridine, purine, benzopyran, benzpyrazine, pyridopyrimidine, quinazoline, quinoline, quinolizine, quinoxaline, the bicycloheteroaryl group is between 9-11 membered bicycloheteroaryl with 5-10 membered heteroaryl being particularly preferred

Biocell 45, 16871694

PMID: 18468679

Subsequently, images were binarised using a suitable thresholding technique to identify these structures distinctly

Van Haren RM, Rajaram R, Correa AM, Mehran RJ, Antonoff MB, Hofstetter WL, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Rice DC, Roth JA