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Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

Beyond mutation profiling, genomic data enables characterization of predictive, prognostic, and diagnostic biomarkers and new therapeutic targets based on differential gene expression studies

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Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

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SHIN1 restores proper proliferation and differentiation programs and reduces inflammatory gene expression in psoriatic skin explants To validate the inhibitory effects of SHIN1 in human disease tissue, lesional skin biopsies from patients with plaque-type psoriasis ( n =5) were cultured ex vivo with or without SHIN1 for 24 h