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It is known that motor neurons are particularly susceptible to free radicals generated during ischemia, and therefore chronic deficits in neural perfusion may contribute to the development of neuronal damage and disease progression (Kalaria 2002

Effects of Tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-masked placebo-controlled phase 3 trials with safety extension data

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HFD BE 666 mg kg -1 d -1 5 times/ wk OG TP: 12 wk Groups 3, 4: #fat accumulation, Lpl, Srebf1, Fabp4, Ucp2, Ppara, #SREBP-1c and ACTA2 Group 4: #Nr1h3, Fasn, Cebpa, Col1a1, #LPL, 4-HNE, nuclear NRF2, HO-1, GPx enzymatic activity Groups 3, 4: "HDL, #TG, TC, LDL, AI, 4-HNE, #GOT, GPT, GPx, and HO-1 plasma enzy- matic activity Group 3: #epididymal and ret- roperitoneal fat Hu et al, 2020 33 Morus alba L