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doi:10.1136/jcp.52.5.385

Mitochondria, which import GSH yet have no disulfide-dithiol exchange exchange with the cytosol [99], have their own dedicated Trx system (TrxR2, Trx2, and Prx3) and GSH system (Gsr, Grx2, 3, and 5, and Gpx1, 3, and 4)

Most transporters share the specific transport capacity with other neutral or cationic amino acids

More intensive needs like severe dehydration or acute illness recovery may require sessions every one to two days until symptoms stabilize, while specialized protocols like NAD+ IV therapy follow a structured loading phase before transitioning to quarterly or monthly maintenance