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For individuals with type 2 diabetes, low blood sugar levels (hypoglycemia) can be a concern when GLP-1 agonists are used in combination with other glucose-lowering medications, such as sulfonylureas or insulin

doi: 10.3389/fphar.2025.1737199 Received 01 November 2025 Revised 21 December 2025 Accepted 29 December 2025 Published 15 January 2026 Volume 16 - 2025 Edited by Dawei Chen, University of Kiel, Germany Reviewed by Eveljn Scarian, University of Pavia, Italy Hong Cheng, Yangzhou University, China Updates Copyright 2026 Knudsen, Tadje, Coggins and Venketaraman

Besides a depletion of Gln, GGT from gastric helicobacters also causes degradation of GSH 15,16

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In this regulatory network, the upregulation of c-MYC , as an important oncogenic transcription factor, not only directly promotes the expression of cell cycle proteins, but also participates in the regulation of cell metabolism, apoptosis, and proliferation, and other aspects of biological processes