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Addition of R-lipoic acid increases ATP synthesis and aortic blood flow during reoxygenation after hypoxia while S-lipoic acid had no effect on ATP synthesis and improved blood flow at only 10-fold the effective dose of R-lipoic

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These subcellular alterations not only directly damage structural cells (e.g., airway epithelium) but also release damage-associated molecular patterns (DAMPs) and oxidized lipids that activate and recruit immune cells ( 3 Immune cells in COPD Immune cells are integral to COPD pathogenesis, driving chronic inflammation, tissue damage, and airway remodeling

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