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In addition, intracellular scaffold proteins interface with the actin cytoskeleton, linking transmembrane tight junction proteins to the cytoskeleton and subsequently acting as a molecular target for tight junction dysregulation in various pathways, including the Zot and zonulin pathways, which both involve the dysregulation of tight junction proteins to induce alterations in intestinal permeability (7, 1115)

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Compromised intestinal barrier function has been associated with a number of disease states, both intestinal and systemic

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These cells release IL-10 and TGF-, which suppress DC maturation and function, ultimately impairing CD8 T-cell priming